Anti-Nociceptive Effect of the Fruit Essential Oil of Cuminum cyminum L. in Rat
نویسندگان
چکیده مقاله:
Cuminum cyminum Linn. (Umbelliferae) is a plant, which has been used as a toothache remedy in folk medicine of Iran. In this study, the potential anti-nociceptive and anti-inflammatory activities of the fruit essential oil of C. cyminum has been evaluated in chemical (formalin test) and thermal (tail-flick test) models of nociception and formalin model of acute inflammation in rats and mice. The essential oil at the doses ranging between 0.0125 and 0.20 ml/kg exhibited a significant and dose-dependent analgesic effect in the model of chronic and inflammatory pain. However, the essential oil was devoid of anti-inflammatory activity. Moreover, the essential oil had no analgesic effect in tail flick test as a model of acute pain. The LD50 value of 0.59 ml/kg was obtained for the essential oil. This low toxicity of the essential oil makes it worthy for further studies
منابع مشابه
anti-nociceptive effect of the fruit essential oil of cuminum cyminum l. in rat
cuminum cyminum linn. (umbelliferae) is a plant, which has been used as a toothache remedy in folk medicine of iran. in this study, the potential anti-nociceptive and anti-inflammatory activities of the fruit essential oil of c. cyminum has been evaluated in chemical (formalin test) and thermal (tail-flick test) models of nociception and formalin model of acute inflammation in rats and mice. th...
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متن کاملThe Effect of Solopotasse Fertilizer on Yield and Essential Oil of Cumin (Cuminum Cyminum L.)
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عنوان ژورنال
دوره 6 شماره 4
صفحات 141- 145
تاریخ انتشار 2002-10
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